TY  - JOUR
PY  - 2015//
TI  - The relationship between neuron-specific enolase and prognosis of patients with acute traumatic brain injury
JO  - Zhongguo Xian Dai Shen Jing Ji Bing Za Zhi
A1  - Liu, Yun-yang
A1  - Ma, Jing-jian
A1  - Li, Jin
A1  - Jia, Rui-chao
SP  - 235
EP  - 239
VL  - 15
IS  - 3
N2  - OBJECTIVE  To investigate the relationship between  neuron-specific enolase (NSE) levels in serum and cerebrospinal fluid (CSF) of  patients with acute traumatic brain injury (TBI) and the prognosis of TBI  patients.   Methods   A total of 89 patients with acute TBI were  divided into light, medium, heavy and severe TBI groups based on admission  Glasgow Coma Scale (GCS) score. Serum NSE expression levels were detected in all  cases and NSE levels in CSF were detected in 18 cases within 12 h after TBI. The  expression levels of serum NSE in 20 normal people, except cases of lung disease  and nervous system damage, were detected as a control group. <br><br>RESULTS  Compared with the control group, serum NSE expression  levels of patients in each TBI group were elevated ( P  < 0.05, for  all), and the NSE levels in severe and heavy TBI groups were higher than that in  medium and light groups ( P  < 0.05, for all). The serum NSE  expression levels of patients with cerebral contusion were higher than that of  patients with diffuse axonal injury (DAI,  P  = 0.025), subdural hematoma  ( P  = 0.031) and epidural hematoma ( P  = 0.021). Serum NSE  expression levels were negatively correlated with GCS score  ( r s   = - 0.327,  P  = 0.024) and Glasgow Outcome Scale  (GOS) score ( r s   = - 0.252,  P  = 0.049). The NSE  expression levels of CSF in severe and heavy TBI patients were higher than that  of serum ( P  = 0.039, 0.031).   Conclusions  NSE  expression changes can be evaluated as an auxiliary indicator in reflecting the  degree of acute TBI, typing diagnosis and prognostic evaluation, and NSE levels  of CSF is more sensitive than that of serum.     DOI:  10.3969/j.issn.1672-6731.2015.03.013<p />  <p>Language: en</p>
LA  - en
SN  - 1672-6731
UR  - http://dx.doi.org/10.3969/cjcnn.v15i3.1162
ID  - ref1
ER  -