TY  - JOUR
PY  - 2016//
TI  - Antidepressant use and recurrent falls in community-dwelling older adults: findings from the Health ABC Study
JO  - Annals of pharmacotherapy
A1  - Marcum, Zachary A.
A1  - Perera, Subashan
A1  - Thorpe, Joshua M.
A1  - Switzer, Galen E.
A1  - Castle, Nicholas G.
A1  - Strotmeyer, Elsa S.
A1  - Simonsick, Eleanor M.
A1  - Ayonayon, Hilsa N.
A1  - Phillips, Caroline L.
A1  - Rubin, Susan
A1  - Zucker-Levin, Audrey R.
A1  - Bauer, Douglas C.
A1  - Shorr, Ronald I.
A1  - Kang, Yihuang
A1  - Gray, Shelly L.
A1  - Hanlon, Joseph T.
SP  - 525
EP  - 533
VL  - 50
IS  - 7
N2  - BACKGROUND: Few studies have compared the risk of recurrent falls across various antidepressant agents-using detailed dosage and duration data-among community-dwelling older adults, including those who have a history of a fall/fracture. <br><br>OBJECTIVE: To examine the association of antidepressant use with recurrent falls, including among those with a history of falls/fractures, in community-dwelling elders. <br><br>METHODS: This was a longitudinal analysis of 2948 participants with data collected via interview at year 1 from the Health, Aging and Body Composition study and followed through year 7 (1997-2004). Any antidepressant medication use was self-reported at years 1, 2, 3, 5, and 6 and further categorized as (1) selective serotonin reuptake inhibitors (SSRIs), (2) tricyclic antidepressants, and (3) others. Dosage and duration were examined. The outcome was recurrent falls (≥2) in the ensuing 12-month period following each medication data collection. <br><br>RESULTS: Using multivariable generalized estimating equations models, we observed a 48% greater likelihood of recurrent falls in antidepressant users compared with nonusers (adjusted odds ratio [AOR] = 1.48; 95% CI = 1.12-1.96). Increased likelihood was also found among those taking SSRIs (AOR = 1.62; 95% CI = 1.15-2.28), with short duration of use (AOR = 1.47; 95% CI = 1.04-2.00), and taking moderate dosages (AOR = 1.59; 95% CI = 1.15-2.18), all compared with no antidepressant use. Stratified analysis revealed an increased likelihood among users with a baseline history of falls/fractures compared with nonusers (AOR = 1.83; 95% CI = 1.28-2.63). <br><br>CONCLUSION: Antidepressant use overall, SSRI use, short duration of use, and moderate dosage were associated with recurrent falls. Those with a history of falls/fractures also had an increased likelihood of recurrent falls.<br><br>© The Author(s) 2016.<p />  <p>Language: en</p>
LA  - en
SN  - 1060-0280
UR  - http://dx.doi.org/10.1177/1060028016644466
ID  - ref1
ER  -