TY  - JOUR
PY  - 2016//
TI  - A pilot randomized clinical trial of an intervention to reduce overdose risk behaviors among emergency department patients at risk for prescription opioid overdose
JO  - Drug and alcohol dependence
A1  - Bohnert, Amy S. B.
A1  - Bonar, Erin E.
A1  - Cunningham, Rebecca
A1  - Greenwald, Mark K.
A1  - Thomas, Laura
A1  - Chermack, Stephen
A1  - Blow, Frederic C.
A1  - Walton, Maureen A. L.
SP  - 40
EP  - 47
VL  - 163
IS  - 
N2  - BACKGROUND AND AIMS: Prescription opioid overdose is a significant public health problem. Interventions to prevent overdose risk behaviors among high-risk patients are lacking. This study examined the impact of a motivational intervention to reduce opioid misuse and overdose risk behaviors. <br><br>METHODS: This study was a pilot randomized controlled trial set in a single emergency department (ED) in which, 204 adult, English-speaking patients seeking care who reported prescription opioid misuse during the prior 3 months were recruited. Patients were randomized to either the intervention, a 30-minute motivational interviewing-based session delivered by a therapist plus educational enhanced usual care (EUC), or EUC alone. Participants completed self-reported surveys at baseline and 6 months post-baseline (87% retention rate) to measure the primary outcomes of overdose risk behaviors and the secondary outcome of non-medical opioid use. <br><br>FINDINGS: Participants in the intervention condition reported significantly lower levels of overdose risk behaviors (incidence rate ratio [IRR]=0.72, 95% CI: 0.59-0.87; 40.5% reduction in mean vs. 14.7%) and lower levels of non-medical opioid use (IRR=0.81, 95% CI: 0.70-0.92; 50.0% reduction in mean vs. 39.5%) at follow-up compared to the EUC condition. <br><br>CONCLUSIONS: This study represents the first clinical trial of a behavioral intervention to reduce overdose risk. <br><br>RESULTS indicate that this single motivational enhancement session reduced prescription opioid overdose risk behaviors, including opioid misuse, among adult patients in the ED.<br><br>Copyright © 2016. Published by Elsevier Ireland Ltd.<p />  <p>Language: en</p>
LA  - en
SN  - 0376-8716
UR  - http://dx.doi.org/10.1016/j.drugalcdep.2016.03.018
ID  - ref1
ER  -