TY  - JOUR
PY  - 2016//
TI  - Structural neural correlates of impaired mobility and subsequent decline in executive functions: a 12-month prospective study
JO  - Experimental gerontology
A1  - Hsu, Chun Liang
A1  - Best, John R.
A1  - Chiu, Bryan K.
A1  - Nagamatsu, Lindsay S.
A1  - Voss, Michelle W.
A1  - Handy, Todd C.
A1  - Bolandzadeh, Niousha
A1  - Liu-Ambrose, Teresa
SP  - 27
EP  - 35
VL  - 80
IS  - 
N2  - Impaired mobility, such as falls, may be an early biomarker of subsequent cognitive decline and is associated with subclinical alterations in both brain structure and function. In this 12-month prospective study, we examined whether there are volumetric differences in gray matter and subcortical regions, as well as cerebral white matter, between older fallers and non-fallers. In addition, we assessed whether these baseline volumetric differences are associated with changes in cognitive function over 12months. A total of 66 community-dwelling older adults were recruited and categorized by their falls status. Magnetic resonance imaging occurred at baseline and participants' physical and cognitive performances were assessed at baseline and 12-months. At baseline, fallers showed significantly lower volumes in gray matter, subcortical regions, and cerebral white matter compared with non-fallers. Notably, fallers had significantly lower left lateral orbitofrontal white matter volume. Moreover, lower left lateral orbitofrontal white matter volume at baseline was associated with greater decline in set-shifting performance over 12months. Our data suggest that falls may indicate subclinical alterations in regional brain volume that are associated with subsequent decline in executive functions.<br><br>Copyright © 2015. Published by Elsevier Inc.<p />  <p>Language: en</p>
LA  - en
SN  - 0531-5565
UR  - http://dx.doi.org/10.1016/j.exger.2016.04.001
ID  - ref1
ER  -