TY  - JOUR
PY  - 2016//
TI  - Long-term neuropsychological profiles and their role as mediators of adaptive functioning following traumatic brain injury in early childhood
JO  - Journal of neurotrauma
A1  - Treble-Barna, Amery
A1  - Zhang, Nanhua
A1  - Zang, Huaiyu
A1  - Taylor, H. Gerry
A1  - Yeates, Keith Owen
A1  - Wade, Shari L.
SP  - 353
EP  - 362
VL  - 34
IS  - 2
N2  - The objectives of the study were to characterize long-term neuropsychological outcomes following traumatic brain injury (TBI) sustained during early childhood and determine whether identified neuropsychological impairments mediated the effect of TBI on long-term adaptive functioning. Participants included 16 children with severe TBI, 42 children with moderate TBI, and 72 children with orthopedic injuries (OI) sustained between ages 3 and 7 years. Children completed neuropsychological tests and caregivers completed a structured interview of child adaptive functioning at 6.9 (±1.10) years post injury. Profile analysis and multiple mediator modeling were employed. Children with severe TBI demonstrated poorer fluid reasoning and inhibitory control relative to both children with moderate TBI and OI, as well as slower processing speed relative to the OI group. Both fluid reasoning and processing speed were significant independent mediators of the effect of severe TBI on adaptive functioning. No neuropsychological measure significantly mediated the effect of moderate TBI on adaptive functioning. Children sustaining early severe TBI demonstrate persisting neuropsychological impairments into adolescence and young adulthood. The impact of severe TBI on children's long-term adaptive functioning is mediated in part by its effects on fluid reasoning and processing speed.<p />  <p>Language: en</p>
LA  - en
SN  - 0897-7151
UR  - http://dx.doi.org/10.1089/neu.2016.4476
ID  - ref1
ER  -