TY - JOUR
PY - 2016//
TI - Unraveling a new circuitry for sleep regulation in Parkinson's disease
JO - Neuropharmacology
A1 - Targa, Adriano D. S.
A1 - Rodrigues, Lais S.
A1 - Noseda, Ana Carolina D.
A1 - Aurich, Mariana F.
A1 - Andersen, Monica Levy
A1 - Tufik, Sergio
A1 - da Cunha, Cláudio
A1 - Lima, Marcelo M. S.
SP - 161
EP - 171
VL - 108
IS -
N2 - Sleep disturbances are among the most disabling non-motor symptoms in Parkinson's disease. The pedunculopontine tegmental nucleus and basal ganglia are likely involved in these dysfunctions, as they are affected by neurodegeneration in Parkinson's disease and have a role in sleep regulation. To investigate this, we promoted a lesion in the pedunculopontine tegmental nucleus or substantia nigra pars compacta of male rats, followed by 24 h of REM sleep deprivation. Then, we administrated a dopaminergic D2 receptor agonist, antagonist or vehicle directly in the striatum. After a period of 24 h of sleep-wake recording, we observed that the ibotenic acid infusion in the pedunculopontine tegmental nucleus blocked the so-called sleep rebound effect mediated by REM sleep deprivation, which was reversed by striatal D2 receptors activation. Rotenone infusion in the substantia nigra pars compacta also blocked the sleep rebound, however, striatal D2 receptors activation did not reverse it. In addition, rotenone administration decreased the time spent in NREM sleep, which was corroborated by positive correlations between dopamine levels in both substantia nigra pars compacta and striatum and the time spent in NREM sleep. These findings suggest a new circuitry for sleep regulation in Parkinson's disease, involving the triad composed by pedunculopontine nucleus, substantia nigra pars compacta and striatum, evidencing a potential therapeutic target for the sleep disturbances associated to this pathology.
Copyright © 2016. Published by Elsevier Ltd. Language: en
LA - en
SN - 0028-3908
UR - http://dx.doi.org/10.1016/j.neuropharm.2016.04.018
ID - ref1
ER -