TY  - JOUR
PY  - 2016//
TI  - Decreased regional gray matter volume in suicide attempters compared to suicide non-attempters with major depressive disorders
JO  - Comprehensive psychiatry
A1  - Lee, Yu Jin
A1  - Kim, Soohyun
A1  - Gwak, Ah Reum
A1  - Kim, Seog Ju
A1  - Kang, Seung-Gul
A1  - Na, Kyoung-Sae
A1  - Son, Young-Don
A1  - Park, Juhyun
SP  - 59
EP  - 65
VL  - 67
IS  - 
N2  - OBJECTIVE: This study investigated regional gray matter (GM) volume differences between suicide attempters and suicide non-attempters with major depressive disorder (MDD) and their relationship with psychological risk factors for suicidality. <br><br>METHODS: MDD patients with and without a suicide attempt history (n=19 in each group) participated. The Hamilton Depression Rating Scale, Clinical Global Impression (severity subscale), Scale for Suicide Ideation (SSI), Risk-Rescue Rating (RRR), Beck Hopelessness Scale (BHS), Barrett Impulsivity Scale, Eysenck Personality Questionnaire, and Ways of Coping Checklist (WCCL) were administered. T1-weighted structural magnetic resonance imaging scans were acquired to evaluate changes in GM volume. Voxel-based morphometry was performed using the SPM 8 software package. Two-sample t-tests were used during second-level group comparison analysis; partial correlation analysis controlling for gender and age identified associations between regional GM volume and psychological measures. <br><br>RESULTS: Suicide attempters exhibited significantly decreased GM volume in the left angular gyrus (p<0.001, uncorrected) and right cerebellum (p<0.001, uncorrected). GM volume in the left angular gyrus was inversely correlated with BHS scores (r=-0.55, p<0.01) and positively correlated with the Seeking Social Support subscale of the WCCL (r=0.43, p<0.01). <br><br>CONCLUSION: These findings provide evidence of a neural basis of suicidal behaviors in MDD. In particular, reduced GM volume in the left angular gyrus may be a neurobiological marker of suicidality in depressed patients.<br><br>Copyright © 2016 Elsevier Inc. All rights reserved.<p />  <p>Language: en</p>
LA  - en
SN  - 0010-440X
UR  - http://dx.doi.org/10.1016/j.comppsych.2016.02.013
ID  - ref1
ER  -