TY  - JOUR
PY  - 2016//
TI  - Heart rate variability and suicidal behavior
JO  - Psychiatry research
A1  - Wilson, Scott T.
A1  - Chesin, Megan
A1  - Fertuck, Eric
A1  - Keilp, John
A1  - Brodsky, Beth
A1  - Mann, J. John
A1  - Sönmez, Cemile Ceren
A1  - Benjamin-Phillips, Christopher
A1  - Stanley, Barbara
SP  - 241
EP  - 247
VL  - 240
IS  - 
N2  - Identification of biological indicators of suicide risk is important given advantages of biomarker-based models. Decreased high frequency heart rate variability (HF HRV) may be a biomarker of suicide risk. The aim of this research was to determine whether HF HRV differs between suicide attempters and non-attempters. Using the Trier Social Stress Test (TSST), we compared HF HRV between females with and without a history of suicide attempt, all with a lifetime diagnosis of a mood disorder. To investigate a potential mechanism explaining association between HF HRV and suicide, we examined the association between self-reported anger and HF HRV. <br><br>RESULTS of an Area under the Curve (AUC) analysis showed attempters had a lower cumulative HF HRV during the TSST than non-attempters. In addition, while there was no difference in self-reported anger at baseline, the increase in anger was greater in attempters, and negatively associated with HF HRV. <br><br>RESULTS suggest that suicide attempters have a reduced capacity to regulate their response to stress, and that reduced capacity to regulate anger may be a mechanism through which decreased HF HRV can lead to an increase in suicide risk. Our results have implications for the prevention of suicidal behavior in at-risk populations.<br><br>Copyright © 2016 Elsevier Ireland Ltd. All rights reserved.<p />  <p>Language: en</p>
LA  - en
SN  - 0165-1781
UR  - http://dx.doi.org/10.1016/j.psychres.2016.04.033
ID  - ref1
ER  -