TY  - JOUR
PY  - 2016//
TI  - The synthesis and investigation of impurities found in clandestine laboratories: Baeyer-Villiger Route Part I; synthesis of P2P from benzaldehyde and methyl ethyl ketone
JO  - Forensic science international
A1  - Doughty, David
A1  - Painter, Ben
A1  - Pigou, Paul E.
A1  - Johnston, Martin R.
SP  - 55
EP  - 66
VL  - 263
IS  - 
N2  - The synthesis of impurities detected in clandestinely manufactured Amphetamine Type Stimulants (ATS) has emerged as more desirable than simple "fingerprint" profiling. We have been investigating the impurities formed when phenyl-2-propanone (P2P) 5, a key ATS precursor, is synthesised in three steps; an aldol condensation of benzaldehyde and methyl ethyl ketone (MEK); a Baeyer-Villiger reaction; and ester hydrolysis. We have identified and selectively synthesised several impurities that may be used as route specific markers for this series of synthetic steps. Specifically these impurities are 3-methyl-4-phenyl-3-buten-2-one 3, 2-methyl-1,5-diphenylpenta-1,4-diene-3-one 9, 2-(methylamino)-3-methyl-4-phenyl-3-butene 16, 2-(Methylamino)-3-methyl-4-phenylbutane 17, and 1-(methylamino)-2-methyl-1,5-diphenylpenta-4-ene-3-one 22.<br><br>Copyright © 2016 Elsevier Ireland Ltd. All rights reserved.<p />  <p>Language: en</p>
LA  - en
SN  - 0379-0738
UR  - http://dx.doi.org/10.1016/j.forsciint.2016.03.034
ID  - ref1
ER  -