TY  - JOUR
PY  - 2016//
TI  - Bidirectional changes in anisotropy are associated with outcomes in mild traumatic brain injury
JO  - AJNR. American journal of neuroradiology
A1  - Strauss, S. B.
A1  - Kim, N.
A1  - Branch, Craig A.
A1  - Kahn, M. E.
A1  - Kim, M.
A1  - Lipton, R. B.
A1  - Provataris, J. M.
A1  - Scholl, H. F.
A1  - Zimmerman, M. E.
A1  - Lipton, M. L.
SP  - ePub
EP  - ePub
VL  - ePub
IS  - ePub
N2  - BACKGROUND AND PURPOSE: Mild traumatic brain injury results in a heterogeneous constellation of deficits and symptoms that persist in a subset of patients. This prospective longitudinal study identifies early diffusion tensor imaging biomarkers of mild traumatic brain injury that significantly relate to outcomes at 1 year following injury. <br><br>MATERIALS AND METHODS: DTI was performed on 39 subjects with mild traumatic brain injury within 16 days of injury and 40 controls; 26 subjects with mild traumatic brain injury returned for follow-up at 1 year. We identified subject-specific regions of abnormally high and low fractional anisotropy and calculated mean fractional anisotropy, axial diffusivity, radial diffusivity, and mean diffusivity across all white matter voxels brain-wide and each of several white matter regions. Assessment of cognitive performance and symptom burden was performed at 1 year. <br><br>RESULTS: Significant associations of brain-wide DTI measures and outcomes included the following: mean radial diffusivity and mean diffusivity with memory; and mean fractional anisotropy, radial diffusivity, and mean diffusivity with health-related quality of life. Significant differences in outcomes were found between subjects with and without abnormally high fractional anisotropy for the following white matter regions and outcome measures: left frontal lobe and left temporal lobe with attention at 1 year, left and right cerebelli with somatic postconcussion symptoms at 1 year, and right thalamus with emotional postconcussion symptoms at 1 year. <br><br>CONCLUSIONS: Individualized assessment of DTI abnormalities significantly relates to long-term outcomes in mild traumatic brain injury. Abnormally high fractional anisotropy is significantly associated with better outcomes and might represent an imaging correlate of postinjury compensatory processes.<br><br>© 2016 American Society of Neuroradiology.<p />  <p>Language: en</p>
LA  - en
SN  - 0195-6108
UR  - http://dx.doi.org/10.3174/ajnr.A4851
ID  - ref1
ER  -