TY  - JOUR
PY  - 2016//
TI  - Effects of omega-3 polyunsaturated fatty acids on psychophysiological symptoms of post-traumatic stress disorder in accident survivors: a randomized, double-blind, placebo-controlled trial
JO  - Journal of affective disorders
A1  - Matsumura, Kenta
A1  - Noguchi, Hiroko
A1  - Nishi, Daisuke
A1  - Hamazaki, Kei
A1  - Hamazaki, Tomohito
A1  - Matsuoka, Yutaka J.
SP  - 27
EP  - 31
VL  - 224
IS  - 
N2  - BACKGROUND: Psychophysiological symptoms (e.g., pounding heart) are known to be a prominent feature of post-traumatic stress disorder (PTSD). Although omega-3 polyunsaturated fatty acids (PUFAs) have a beneficial potential pharmacological effect of preventing these psychophysiological symptoms, no clinical data is yet available. Therefore, we conducted a randomized, double-blind, placebo-controlled trial of Japanese accident survivors. <br><br>METHODS: A total of 83 participants received either omega-3 PUFAs (1470mg docosahexaenoic acid and 147mg eicosapentaenoic acid per day) or placebo within 10 days of the accidental injury. After 12-week supplementation, participants performed script-driven imagery of their traumatic event during monitoring of their heart rate and skin conductance. <br><br>RESULTS: Analysis revealed that heart rate during both rest and script-driven imagery was significantly lower in the omega-3 group than the placebo group, whereas baseline heart rate was comparable between the two groups. LIMITATIONS: The present trial was conducted at a single-center in Japan and psychophysiological symptoms of PTSD in most participants were not serious. <br><br>CONCLUSION: These findings suggest that post-trauma supplementation of omega-3 PUFAs might be effective for the secondary prevention of psychophysiological symptoms of PTSD.<br><br>Copyright © 2016 Elsevier B.V. All rights reserved.<p />  <p>Language: en</p>
LA  - en
SN  - 0165-0327
UR  - http://dx.doi.org/10.1016/j.jad.2016.05.054
ID  - ref1
ER  -