TY  - JOUR
PY  - 2016//
TI  - FKBP5 interacts with maltreatment in children with extreme, pervasive, and persistent aggression
JO  - Psychiatry research
A1  - Bryushkova, Lyubov
A1  - Zai, Clement
A1  - Chen, Sheng
A1  - Pappa, Irene
A1  - Mileva, Viara
A1  - Tiemeier, Henning
A1  - Bakermans-Kranenburg, Marian
A1  - Kennedy, James L.
A1  - Beitchman, Joseph H.
SP  - 277
EP  - 280
VL  - 242
IS  - 
N2  - Genetic variation in stress response protein FKBP5 is associated with adult psychopathology, but little is known about its role in children's mental health. 5 polymorphisms were genotyped in 170 high aggression cases and 170 age- and sex-matched controls. The rs9470080 polymorphism was associated with physiological anxiety, while rs4713916 polymorphism interacted with maltreatment to influence externalizing traits. These results suggest that genetic variation in FKBP5 has a role in children's vulnerability to stress-related behaviours.<br><br>Copyright © 2016 Elsevier Ireland Ltd. All rights reserved.<p />  <p>Language: en</p>
LA  - en
SN  - 0165-1781
UR  - http://dx.doi.org/10.1016/j.psychres.2015.09.052
ID  - ref1
ER  -