TY  - JOUR
PY  - 2016//
TI  - Circadian regulation of human cortical excitability
JO  - Nature communications
A1  - Ly, Julien Q. M.
A1  - Gaggioni, Giulia
A1  - Chellappa, Sarah L.
A1  - Papachilleos, Soterios
A1  - Brzozowski, Alexandre
A1  - Borsu, Chloé
A1  - Rosanova, Mario
A1  - Sarasso, Simone
A1  - Middleton, Benita
A1  - Luxen, Andre
A1  - Archer, Simon N.
A1  - Phillips, Christophe
A1  - Dijk, Derk-Jan
A1  - Maquet, Pierre
A1  - Massimini, Marcello
A1  - Vandewalle, Gilles
SP  - e11828
EP  - e11828
VL  - 7
IS  - 
N2  - Prolonged wakefulness alters cortical excitability, which is essential for proper brain function and cognition. However, besides prior wakefulness, brain function and cognition are also affected by circadian rhythmicity. Whether the regulation of cognition involves a circadian impact on cortical excitability is unknown. Here, we assessed cortical excitability from scalp electroencephalography (EEG) responses to transcranial magnetic stimulation in 22 participants during 29 h of wakefulness under constant conditions. Data reveal robust circadian dynamics of cortical excitability that are strongest in those individuals with highest endocrine markers of circadian amplitude. In addition, the time course of cortical excitability correlates with changes in EEG synchronization and cognitive performance. These results demonstrate that the crucial factor for cortical excitability, and basic brain function in general, is the balance between circadian rhythmicity and sleep need, rather than sleep homoeostasis alone. These findings have implications for clinical applications such as non-invasive brain stimulation in neurorehabilitation.<p />  <p>Language: en</p>
LA  - en
SN  - 2041-1723
UR  - http://dx.doi.org/10.1038/ncomms11828
ID  - ref1
ER  -