TY  - JOUR
PY  - 2016//
TI  - Counterfeit adderall containing aceclofenac from internet pharmacies
JO  - Journal of forensic sciences
A1  - Gaudiano, Maria Cristina
A1  - Borioni, Anna
A1  - Antoniella, Eleonora
A1  - Valvo, Luisa
SP  - 1126
EP  - 1130
VL  - 61
IS  - 4
N2  - A nontargeted approach based on liquid chromatography equipped with a quadrupole time-of-flight mass detector (LC-MS Q-TOF) joined to nuclear magnetic resonance (NMR) analysis allowed rapid identification and quantification of the anti-inflammatory drug aceclofenac in illegal Adderall tablets. The largest chromatographic peak had m/z = 354.030 and m/z = 376.012 matching, respectively, the ionic structures (M + H)(+) and (M + Na)(+) of a molecule M. The accurate mass data generated the molecular formula C16 H13 Cl2 NO4. A screening of the pharmaceutical active substances having that molecular formula together with the MS/MS fragmentation pattern suggested aceclofenac. Aceclofenac structure was unambiguously confirmed by (1) H and (13) C NMR experiments. The aceclofenac content was 90 mg/tablet (RSD 2%) as detected by quantitative NMR. Information on the identity and content of illegal drugs is required for legal purposes; it supports in evaluating the effective impact on users safety, and it is useful for control laboratories using a targeted approach in their analytical activities.<br><br>© 2016 American Academy of Forensic Sciences.<p />  <p>Language: en</p>
LA  - en
SN  - 0022-1198
UR  - http://dx.doi.org/10.1111/1556-4029.13095
ID  - ref1
ER  -