TY  - JOUR
PY  - 2016//
TI  - Genetics and other risk factors for past concussions in active-duty soldiers
JO  - Journal of neurotrauma
A1  - Dretsch, Michael
A1  - Silverberg, Noah D.
A1  - Gardner, Andrew
A1  - Panenka, William
A1  - Emmerich, Tanja
A1  - Crynen, Gogce
A1  - Ait-Ghenzala, Ghania
A1  - Chaytow, Helena
A1  - Mathura, Venkatarajan
A1  - Crawford, Fiona C.
A1  - Iverson, Grant L.
SP  - 869
EP  - 875
VL  - 34
IS  - 4
N2  - Risk factors for concussion in active-duty military service members are poorly understood. The present study examined the association between self-reported concussion history and genetics [Apolipoprotein E (APOE), brain-derived neurotrophic factor (BDNF), and D2 dopamine receptor genes (DRD2)], trait personality measures (impulsive-sensation seeking and trait aggression-hostility), and current alcohol use. The sample included 458 soldiers who were preparing to deploy for Operation Iraqi Freedom/Operation Enduring Freedom. For those with the BDNF Met/Met genotype, 57.9% (11/19) had a history of 1 or more prior concussions, compared to 35.6% (154/432) of those with other BDNF genotypes (p =.049, OR = 2.48). APOE and DRD2 genotypes were not associated with risk for past concussions. Those with the BDNF Met/Met genotype also reported greater aggression and hostility personality characteristics. When combined in a predictive model, prior military deployments, being male, and having the BDNF Met/Met genotype were independently associated with increased lifetime history of concussions in active-duty soldiers. Replication in larger independent samples is necessary to have more confidence in both the positive and negative genetic associations reported in this study.<p />  <p>Language: en</p>
LA  - en
SN  - 0897-7151
UR  - http://dx.doi.org/10.1089/neu.2016.4480
ID  - ref1
ER  -