TY  - JOUR
PY  - 2016//
TI  - From alcohol initiation to tolerance to problems: discordant twin modeling of a developmental process
JO  - Development and psychopathology
A1  - Deutsch, Arielle R.
A1  - Slutske, Wendy S.
A1  - Lynskey, Michael T.
A1  - Bucholz, Kathleen K.
A1  - Madden, Pamela A. F.
A1  - Heath, Andrew C.
A1  - Martin, Nicholas G.
SP  - 845
EP  - 861
VL  - 29
IS  - 3
N2  - The current study examined a stage-based alcohol use trajectory model to test for potential causal effects of earlier drinking milestones on later drinking milestones in a combined sample of two cohorts of Australian monozygotic and same-sex dizygotic twins (N = 7,398, age M = 30.46, SD = 2.61, 61% male, 56% monozygotic twins). Ages of drinking, drunkenness, regular drinking, tolerance, first nontolerance alcohol use disorder symptom, and alcohol use disorder symptom onsets were assessed retrospectively. Ages of milestone attainment (i.e., age-of-onset) and time between milestones (i.e., time-to-event) were examined via frailty models within a multilevel discordant twin design. For age-of-onset models, earlier ages of onset of antecedent drinking milestones increased hazards for earlier ages of onset for more proximal subsequent drinking milestones. For the time-to-event models, however, earlier ages of onset for the "starting" milestone decreased risk for a shorter time period between the starting and the "ending" milestone. Earlier age of onset of intermediate milestones between starting and ending drinking milestones had the opposite effect, increasing risk for a shorter time period between the starting and ending milestones. These results are consistent with a causal effect of an earlier age of drinking milestone onset on temporally proximal subsequent drinking milestones.<p />  <p>Language: en</p>
LA  - en
SN  - 0954-5794
UR  - http://dx.doi.org/10.1017/S0954579416000523
ID  - ref1
ER  -