TY  - JOUR
PY  - 2016//
TI  - Falls among middle-aged women in the Women's Interagency HIV Study
JO  - Antiviral therapy
A1  - Sharma, Anjali
A1  - Hoover, Donald R.
A1  - Shi, Qiuhu
A1  - Holman, Susan
A1  - Plankey, Michael W.
A1  - Wheeler, Amber L.
A1  - Weber, Kathleen
A1  - Floris-Moore, Michelle
A1  - Bolivar, Hector H.
A1  - Vance, David E.
A1  - Mack, Wendy J.
A1  - Golub, Elizabeth T.
A1  - Holstad, Marcia McDonnell
A1  - Yin, Michael T.
SP  - 697
EP  - 706
VL  - 21
IS  - 8
N2  - BACKGROUND: To determine the frequency and risk factors for falls among middle-aged HIV+ and HIV- women in the Women's Interagency HIV Study (WIHS). <br><br>METHODS: We quantified self-report of any and multiple (≥2 falls) in the prior 6 months among 1,412 HIV+ and 650 HIV- women with mean age 48 years. Logistic regression was used to evaluate associations of demographics, behavioral factors, comorbid conditions, and medications with odds of any fall (vs. none) and multiple falls (vs. ≤1 fall). <br><br>RESULTS: At least one fall was reported in 263 HIV+ (19%) vs. 119 HIV- (18%) women, and ≥2 falls reported in 133 HIV+ (9%) vs. 65 HIV- (10%) women. HIV infection was not associated with falls in multivariate analyses. Factors independently associated with any fall included age (aOR 1.71, 95% CI:1.17-2.49 age 50-59 vs. <39y; aOR 2.26, 95% CI:1.38-3.71 age ≥60 vs. <39), current marijuana use (aOR 2.19, 95% CI:1.53-3.13) depressive symptoms (aOR 1.57, 95% CI:1.21-2.05 for CES-D ≥16), subjective cognitive complaints (aOR 2.19, 95% CI:1.56-3.08), neuropathy (aOR 1.59, 95% CI:1.19-2.13), obesity (aOR 1.39, 95% CI:1.08-1.80), number of CNS active agents (aOR 2.98, 95% CI:1.90-4.68 for ≥3 agents vs. 0) and WIHS site. Factors associated with ≥2 falls included age, marijuana use, number of CNS active agents, subjective cognitive complaints, depressive symptoms, neuropathy, and study site. <br><br>CONCLUSIONS: Falls were associated with factors affecting cognition, but not HIV status in this large cohort of women. Longitudinal studies are needed to determine the incidence and consequences of falls by HIV status as women age.<p />  <p>Language: en</p>
LA  - en
SN  - 1359-6535
UR  - http://dx.doi.org/10.3851/IMP3070
ID  - ref1
ER  -