TY  - JOUR
PY  - 1994//
TI  - The fluoxetine and suicide controversy : a review of the evidence
JO  - CNS drugs
A1  - Healy, D.
SP  - 223
EP  - 231
VL  - 1
IS  - 3
N2  - Evidence is emerging that a range of psychotropic drugs may precipitate akathisia and/or panic reactions in predisposed patients. The use of fluoxetine has hitherto been the most notable example of this occurrence. These reactions may foster the genesis of suicidal ideation in a small proportion of patients. At present, it is not clear what biological mechanism may underlie this finding. The serotonin (5-hydroxytryptarnine; 5-HT) system may be involved in these reactions.The best management of such reactions will involve counselling patients beforehand about the possibility of these reactions, stopping treatment with the agents if such a reaction is suspected, or adding an agent with 5-HT1A antagonistic properties (e.g. propranolol) to the treatment regimen.<p />  <p>Language: en</p>
LA  - en
SN  - 1172-7047
UR  - http://dx.doi.org/10.2165/00023210-199401030-00007
ID  - ref1
ER  -