TY  - JOUR
PY  - 2016//
TI  - Effects of social isolation, re-socialization and age on cognitive and aggressive behaviors of Kunming mice and BALB/c mice
JO  - Animal science journal
A1  - An, Dong
A1  - Chen, Wenxue
A1  - Yu, De-Qin
A1  - Wang, Shi-Wei
A1  - Yu, Wei-Zhi
A1  - Xu, Hong
A1  - Wang, Dong-Mei
A1  - Zhao, Dan
A1  - Sun, Yi-Ping
A1  - Wu, Jun-Cheng
A1  - Tang, Yi-Yuan
A1  - Yin, Sheng-Ming
SP  - 798
EP  - 806
VL  - 88
IS  - 5
N2  - Both Kunming (KM) mice and BALB/c mice have been widely used as rodent models to investigate stress-associated mental diseases. However, little is known about the different behaviors of KM mice and BALB/c mice after social isolation, particularly cognitive and aggressive behaviors. In this study, the behaviors of KM and BALB/c mice isolated for 2, 4 and 8 weeks and age-matched controls were evaluated using object recognition, object location and resident-intruder tests. The recovery of behavioral deficits by re-socialization was also examined for the isolated mice in adolescence. Our study showed that isolation for 2, 4 and 8 weeks led to cognitive deficits and increased aggressiveness for both KM and BALB/c mice. An important finding is that re-socialization could completely recover spatial/non-spatial cognitive deficits resulted from social isolation for both KM and BALB/c mice. In addition, age only impacted aggressiveness of KM mice. Moreover, isolation duration showed different impacts on cognitive and aggressive behaviors for both KM and BALB/c mice. Furthermore, BALB/c mice showed weak spatial/non-spatial memory and low aggressiveness when they were at the same age and isolation duration, compared to KM mice. In conclusion, KM mice and BALB/c mice behaved characteristically under physiology and isolation conditions.<br><br>© 2016 Japanese Society of Animal Science.<p />  <p>Language: en</p>
LA  - en
SN  - 1344-3941
UR  - http://dx.doi.org/10.1111/asj.12688
ID  - ref1
ER  -