TY  - JOUR
PY  - 2016//
TI  - Oxidation-reduction potential as a biomarker for severity and acute outcome in traumatic brain injury
JO  - Oxidative medicine and cellular longevity
A1  - Bjugstad, Kimberly B.
A1  - Rael, Leonard T.
A1  - Levy, Stewart
A1  - Carrick, Matthew
A1  - Mains, Charles W.
A1  - Slone, Denetta S.
A1  - Bar-Or, David
SP  - e6974257
EP  - e6974257
VL  - 2016
IS  - 
N2  - There are few reliable markers for assessing traumatic brain injury (TBI). Elevated levels of oxidative stress have been observed in TBI patients. We hypothesized that oxidation-reduction potential (ORP) could be a potent biomarker in TBI. Two types of ORP were measured in patient plasma samples: the static state of oxidative stress (sORP) and capacity for induced oxidative stress (icORP). Differences in ORP values as a function of time after injury, severity, and hospital discharge were compared using ANOVAs with significance at p ≤ 0.05. Logit regression analyses were used to predict acute outcome comparing ORP, Injury Severity Score (ISS), Abbreviated Injury Scale (AIS), and Glasgow Coma Scale (GCS). Antioxidant capacity (icORP) on day 4 was prognostic for acute outcomes (p < 0.05). An odds ratio of 4.08 was associated with poor acute outcome when icORP > 7.25 μC. IcORP was a better predictor than ISS, AIS, or GCS scores. sORP increased in those with the highest ISS values (p < 0.05). Based on these findings ORP is useful biomarker for severity and acute outcome in TBI patients. Changes in ORP values on day 4 after injury were the most prognostic, suggesting that patients' response to brain injury over time is a factor that determines outcome.<p />  <p>Language: en</p>
LA  - en
SN  - 1942-0900
UR  - http://dx.doi.org/10.1155/2016/6974257
ID  - ref1
ER  -