TY  - JOUR
PY  - 2016//
TI  - Associations between family adversity and brain volume in adolescence: manual vs. automated brain segmentation yields different results
JO  - Frontiers in neuroscience
A1  - Lyden, Hannah
A1  - Gimbel, Sarah I.
A1  - Del Piero, Larissa
A1  - Tsai, A. Bryna
A1  - Sachs, Matthew E.
A1  - Kaplan, Jonas T.
A1  - Margolin, Gayla
A1  - Saxbe, Darby
SP  - e398
EP  - e398
VL  - 10
IS  - 
N2  - Associations between brain structure and early adversity have been inconsistent in the literature. These inconsistencies may be partially due to methodological differences. Different methods of brain segmentation may produce different results, obscuring the relationship between early adversity and brain volume. Moreover, adolescence is a time of significant brain growth and certain brain areas have distinct rates of development, which may compromise the accuracy of automated segmentation approaches. In the current study, 23 adolescents participated in two waves of a longitudinal study. Family aggression was measured when the youths were 12 years old, and structural scans were acquired an average of 4 years later. Bilateral amygdalae and hippocampi were segmented using three different methods (manual tracing, FSL, and NeuroQuant). The segmentation estimates were compared, and linear regressions were run to assess the relationship between early family aggression exposure and all three volume segmentation estimates. Manual tracing results showed a positive relationship between family aggression and right amygdala volume, whereas FSL segmentation showed negative relationships between family aggression and both the left and right hippocampi. However, results indicate poor overlap between methods, and different associations were found between early family aggression exposure and brain volume depending on the segmentation method used.<p />  <p>Language: en</p>
LA  - en
SN  - 1662-4548
UR  - http://dx.doi.org/10.3389/fnins.2016.00398
ID  - ref1
ER  -