TY  - JOUR
PY  - 2016//
TI  - Generalized seizures after experimental traumatic brain injury occur at the transition from slow-wave to rapid-eye-movement sleep
JO  - Journal of neurotrauma
A1  - Andrade, Pedro
A1  - Nissinen, Jari
A1  - Pitkänen, Asla
SP  - 1482
EP  - 1487
VL  - 34
IS  - 7
N2  - Sleep disturbances commonly occur after traumatic brain injury and may predispose patients to epileptic seizures. We hypothesized that unprovoked seizure occurrence after traumatic brain injury depends on the sleep-wake cycle, and that the electrographic characteristics of a given sleep stage provide biomarkers for post-traumatic epilepsy. We show in a rat lateral fluid-percussion model that 92% of spontaneous generalized seizures occur during the transition from stage III to rapid-eye-movement sleep. Moreover, a reduction in spindle duration and dominant frequency during the transition stage present as specific and sensitive non-invasive biomarkers for experimentally induced post-traumatic epilepsy with generalized electrographic seizures.<p />  <p>Language: en</p>
LA  - en
SN  - 0897-7151
UR  - http://dx.doi.org/10.1089/neu.2016.4675
ID  - ref1
ER  -