TY  - JOUR
PY  - 2016//
TI  - Novelty during a late postacquisition time window attenuates the persistence of fear memory
JO  - Scientific reports
A1  - Katche, Cynthia
A1  - Tomaiuolo, Micol
A1  - Dorman, Guido
A1  - Medina, Jorge H.
A1  - Viola, Haydee
SP  - e35220
EP  - e35220
VL  - 6
IS  - 
N2  - Learning to avoid threats in the environment is highly adaptive. However, sometimes a dysregulation of fear memories processing may underlie fear-related disorders. Despite recent advances, a major question of how to effectively attenuate persistent fear memories in a safe manner remains unresolved. Here we show experiments employing a behavioural tool to target a specific time window after training to limit the persistence of a fear memory in rats. We observed that exposure to a novel environment 11 h after an inhibitory avoidance (IA) training that induces a long-lasting memory, attenuates the durability of IA memory but not its formation. This effect is time-restricted and not seen when the environment is familiar. In addition, novelty-induced attenuation of IA memory durability is prevented by the intrahippocampal infusion of the CaMKs inhibitor KN-93. This new behavioural approach which targets a specific time window during late memory consolidation, might represent a new tool for reducing the durability of persistent fear memories.<p />  <p>Language: en</p>
LA  - en
SN  - 2045-2322
UR  - http://dx.doi.org/10.1038/srep35220
ID  - ref1
ER  -