TY  - JOUR
PY  - 2016//
TI  - Decreased resting state metabolic activity in frontopolar and parietal brain regions is associated with suicide plans in depressed individuals
JO  - Journal of psychiatric research
A1  - van Heeringen, Cornelis Kees
A1  - Wu, Guo-Rong
A1  - Vervaet, Myriam
A1  - Vanderhasselt, Marie-Anne
A1  - Baeken, Chris
SP  - 243
EP  - 248
VL  - 84
IS  - 
N2  - Suicide plans are a major risk factor for suicide, which is a devastating outcome of depression. While structural and functional brain changes have been demonstrated in relation to suicidal thoughts and behaviour, brain mechanisms underlying suicide plans have not yet been studied. Here, we studied changes in regional cerebral metabolic activity in association with suicide plans in depressed individuals. Using (18)FDG-PET, a comparative study of regional cerebral glucose metabolism (rCMRglu) was carried out in depressed individuals with suicidal thoughts and suicide plans, depressed individuals with only suicidal thoughts, depressed individuals without suicide thoughts and plans, and healthy controls. When compared to the other groups, depressed individuals with suicide plans showed relative hypometabolism in the right middle frontal gyrus and the right inferior parietal lobe (Brodmann areas 10 and 39). Suicide plans in depressed individuals appear to be associated with reduced activity in brain areas that are involved in decision-making and choice, more particularly in exploratory behaviour.<br><br>Copyright © 2016 Elsevier Ltd. All rights reserved.<p />  <p>Language: en</p>
LA  - en
SN  - 0022-3956
UR  - http://dx.doi.org/10.1016/j.jpsychires.2016.10.011
ID  - ref1
ER  -