TY  - JOUR
PY  - 2016//
TI  - Can early clinical parameters predict post-traumatic pituitary dysfunction in severe traumatic brain injury?
JO  - Acta neurochirurgica
A1  - Nemes, O.
A1  - Kovács, N.
A1  - Szujo, Sz
A1  - Bodis, B.
A1  - Bajnok, L.
A1  - Buki, A.
A1  - Doczi, T.
A1  - Czeiter, E.
A1  - Mezosi, E.
SP  - 2347
EP  - 2353
VL  - 158
IS  - 12
N2  - BACKGROUND: Post-traumatic hypopituitarism is a major complication after severe head trauma. The aim of our study was to evaluate the possible role of early clinical parameters in the development of endocrine deficits. <br><br>METHODS: Data on endocrine function, on-admission clinical-, laboratory-, and ICU-monitored parameters were available in 63 patients of the surviving 86 severe head injury patients (post-resuscitation GCS under 8) treated at one neurosurgical center during a 10-year period. <br><br>RESULTS: Hypopituitarism was diagnosed in 68.3 % of the patients. The most frequently affected pituitary axis was the growth hormone (GH): GH deficiency or insufficiency was present in 50.8 %. Central hypogonadism affected 23.8 % of male patients; hypothyroidism and secondary adrenal failure were found in 22.2 and 9.5 % of the investigated population, respectively. Early onset (within 1 year of brain injury) hypopituitarism was found in 24 patients. No connection was found between the development of hypopituitarism and any of the clinical parameters assessed on-admission or at ICU. Significant correlations were found between early endocrine dysfunctions and surgical intervention (OR: 4.64) and the diagnosis of subdural hematoma (OR: 12). In our population, after road traffic accidents, the development of late-onset hypopituitarism was less prevalent (OR: 0.22). <br><br>CONCLUSIONS: Since our results do not indicate any reliable predictive parameter for the development of endocrine dysfunction in a cohort of patients with severe traumatic brain injury, regular endocrine screening of this specific patient population seems obligatory.<p />  <p>Language: en</p>
LA  - en
SN  - 0001-6268
UR  - http://dx.doi.org/10.1007/s00701-016-2995-x
ID  - ref1
ER  -