TY  - JOUR
PY  - 2016//
TI  - Childhood abuse, promoter methylation of leukocyte NR3C1 and the potential modifying effect of emotional support
JO  - Epigenomics
A1  - Shields, Alexandra E.
A1  - Wise, Lauren A.
A1  - Ruiz-Narvaez, Edward A.
A1  - Seddighzadeh, Bobak
A1  - Byun, Hyang-Min
A1  - Cozier, Yvette C.
A1  - Rosenberg, Lynn
A1  - Palmer, Julie R.
A1  - Baccarelli, Andrea A.
SP  - 1507
EP  - 1517
VL  - 8
IS  - 11
N2  - AIM: To investigate childhood abuse victimization in relation to adult DNA methylation levels in a novel region of NR3C1, with emotional support as a possible modifier. MATERIALS & METHODS: 295 participants from the Black Women's Health Study. Multivariable linear regression models were used to compute differences in mean percent methylation levels. <br><br>RESULTS: Women reporting childhood abuse victimization exhibited higher mean NR3C1 methylation levels than nonabused women, with a clear dose-response relationship. Childhood emotional support appeared to attenuate associations only among women with the highest levels of physical and sexual abuse. <br><br>CONCLUSION: NR3C1 mean methylation was higher among women who reported childhood abuse. Further research is warranted to clarify whether or the extent to which childhood emotional support buffers the association.<p />  <p>Language: en</p>
LA  - en
SN  - 1750-1911
UR  - http://dx.doi.org/10.2217/epi-2016-0074
ID  - ref1
ER  -