TY - JOUR PY - 1995// TI - Seasonal rhythm of platelet [3H]imipramine binding in adolescents who attempted suicide JO - American journal of psychiatry A1 - Pine, Daniel S. A1 - Trautman, P. D. A1 - Shaffer, David A1 - Cohen, L. A1 - Davies, Michelle A1 - Stanley, M. A1 - Parsons, B. SP - 923 EP - 925 VL - 152 IS - 6 N2 - OBJECTIVE: This study was designed to determine the seasonality of serotonin functions among adolescents who attempt suicide. METHOD: Platelet [3H]imipramine binding was assessed over a period of 18 months in 98 adolescents who attempted suicide and a comparison group of 23 never-suicidal youths with conduct disorder. RESULTS: [3H]Imipramine (Bmax) was uncorrelated with age, but showed considerable seasonal variability over time in those who had attempted suicide. CONCLUSIONS: [3H]Imipramine binding density in adolescents who attempted suicide exhibited significant seasonality, reaching a nadir in late winter/early spring.
Language: en
LA - en SN - 0002-953X UR - http://dx.doi.org/ ID - ref1 ER -