TY  - JOUR
PY  - 1995//
TI  - Platelet markers in suicide attempters
JO  - Progress in neuro-psychopharmacology and biological psychiatry
A1  - Marazziti, Donatella
A1  - Presta, S.
A1  - Silvestri, Salvatore
A1  - Battistini, Alessio
A1  - Mosti, L.
A1  - Balestri, C.
A1  - Palego, L.
A1  - Conti, Linda
SP  - 375
EP  - 383
VL  - 19
IS  - 3
N2  - 1. The authors measured 3H-imipramine (3H-IMI) binding and serotonin (5HT) uptake parameters as well as sulphotransferase activity in platelets of suicide attempters. 2. Platelet 3H-IMI binding sites and 5HT uptake are related to similar sites and processes present in the brain, and sulphotransferase (ST) is an enzyme involved in the catabolism of cathecholamines. 3. The results showed the presence of a decreased density of both 3H-IMI binding and of 5HT uptake sites, with no change in ST activity in suicide attempters, as compared with healthy controls. 4. The reduced 3H-IMI binding and 5HT uptake may be related to a hypofunction of presynaptic serotonergic mechanisms which might be altered in suicidal behavior.<p />  <p>Language: en</p>
LA  - en
SN  - 0278-5846
UR  - http://dx.doi.org/
ID  - ref1
ER  -