TY  - JOUR
PY  - 2016//
TI  - Familial aggregation of Parkinson's disease may affect progression of motor symptoms and dementia
JO  - Movement disorders
A1  - Gaare, Johannes Jernqvist
A1  - Skeie, Geir Olve
A1  - Tzoulis, Charalampos
A1  - Larsen, Jan Petter
A1  - Tysnes, Ole-Bjørn
SP  - 241
EP  - 245
VL  - 32
IS  - 2
N2  - BACKGROUND: Familial aggregation has been described in PD of both early and late onset, but has not been studied in a true population-based sample. Moreover, little is known about its association with disease progression and endophenotypes. <br><br>OBJECTIVES: The objectives of this work were to determine familial aggregation of idiopathic PD in a population-based cohort and study the association with clinical endophenotypes and disease progression. <br><br>METHODS: We examined family history data from the Norwegian ParkWest study, a well-characterized, population-based cohort of incident PD patients and age-matched healthy controls. Family data were collected at baseline with a simplified questionnaire (192 cases and 193 controls) and after 3 years of longitudinal follow-up using an extended questionnaire (172 cases and 171 controls). <br><br>RESULTS: Compared to the controls, the PD patients had an increased relative risk of having a first-degree relative with PD when using the extended questionnaire (relative risk = 1.988; P = 0.036), but not when using the simplified questionnaire (relative risk = 1.453; P = 0.224). There was no significant difference in age of onset or motor subtype (P = 0.801). However, cases with a family history of PD had reduced progression over 7 years as measured by UPDRS II (P = 0.008) and smaller rate of decrease of MMSE (P = 0.046). <br><br>CONCLUSIONS: Our findings confirm familial aggregation in a population-based cohort of idiopathic PD. Moreover, we show that positive family history of PD in patients is associated with a slower progression of PD symptoms and cognitive decline. © 2016 International Parkinson and Movement Disorder Society.<br><br>© 2016 International Parkinson and Movement Disorder Society.<p />  <p>Language: en</p>
LA  - en
SN  - 0885-3185
UR  - http://dx.doi.org/10.1002/mds.26856
ID  - ref1
ER  -