TY  - JOUR
PY  - 2016//
TI  - Daytime sleepiness and nighttime sleep quality across the full spectrum of cognitive presentations in essential tremor
JO  - Journal of the neurological sciences
A1  - Rohl, Brittany
A1  - Collins, Kathleen
A1  - Morgan, Sarah
A1  - Cosentino, Stephanie
A1  - Huey, Edward D.
A1  - Louis, Elan D.
SP  - 24
EP  - 31
VL  - 371
IS  - 
N2  - There is increasing evidence that essential tremor (ET) is a complex and heterogeneous disorder with nonmotor features including cognitive deficits and sleep problems. We are unaware of a study that has examined sleep deficits in ET across the full spectrum of cognitive presentations. Cross-sectional (baseline) data on self-reported nighttime sleep dysfunction and excessive daytime sleepiness were collected using the Pittsburgh Sleep Quality Index (PSQI) and the Epworth Sleepiness Scale (ESS) in 96 ET cases enrolled in a prospective study. Cases underwent a comprehensive neuropsychological assessment, and were classified as ET with normal cognition (ET-NC), ET with mild cognitive impairment (ET-MCI), and ET with dementia (ET-D). PSQI scores did not significantly differ across the three ET cognitive groups (p=0.22). ESS scores were highest (more daytime sleepiness) in the ET-MCI group, followed by the ET-D and ET-NC groups, respectively (p=0.016). We examined sleep dysfunction across the cognitive spectrum in ET. We demonstrate for the first time that excessive daytime sleepiness is greater in ET-MCI than ET-NC. Unpredicted low ESS scores in the dementia group raises two possibilities: a self-report bias related to cognitive impairment and/or the possibility that currently undefined pathological heterogeneity in ET may map onto multiple presentations of non-motor deficits.<br><br>Copyright © 2016. Published by Elsevier B.V.<p />  <p>Language: en</p>
LA  - en
SN  - 0022-510X
UR  - http://dx.doi.org/10.1016/j.jns.2016.10.006
ID  - ref1
ER  -