TY  - JOUR
PY  - 2016//
TI  - Altered dynamics of brain connectivity in major depressive disorder at-rest and during task performance
JO  - Psychiatry research
A1  - Sambataro, Fabio
A1  - Visintin, Eleonora
A1  - Doerig, Nadja
A1  - Brakowski, Janis
A1  - Holtforth, Martin Grosse
A1  - Seifritz, Erich
A1  - Spinelli, Simona
SP  - 1
EP  - 9
VL  - 259
IS  - 
N2  - Major depressive disorder (MDD) has been associated with alterations in several functional brain networks. Previous studies investigating brain networks in MDD during the performance of a task have yielded inconsistent results with the function of the brain at rest. In this study, we used functional magnetic resonance imaging at rest and during a goal-directed task to investigate dynamics of functional connectivity in 19 unmedicated patients with MDD and 19 healthy controls across both experimental paradigms. Patients had spatial differences in the default mode network (DMN), in the executive network (EN), and in the dorsal attention network (DAN) compared to controls at rest and during task performance. In patients the amplitude of the low frequency (LFO) oscillations was reduced in the motor and in the DAN networks during both paradigms. There was a diagnosis by paradigm interaction on the LFOs amplitude of the salience network, with increased amplitude change between task and rest in patients relative to controls. Our findings suggest that the function of several networks could be intrinsically affected in MDD and this could be viable phenotype for the investigation on the neurobiological mechanisms of this disorder and its treatment.<br><br>Copyright © 2016 The Authors. Published by Elsevier Ireland Ltd.. All rights reserved.<p />  <p>Language: en</p>
LA  - en
SN  - 0165-1781
UR  - http://dx.doi.org/10.1016/j.pscychresns.2016.11.001
ID  - ref1
ER  -