TY  - JOUR
PY  - 2016//
TI  - Paraphilic sexual offenders do not differ from control subjects with respect to dopamine- and serotonin-related genetic polymorphisms
JO  - Journal of sexual medicine
A1  - Jakubczyk, Andrzej
A1  - Krasowska, Aleksandra
A1  - Bugaj, Marcin
A1  - Kopera, Maciej
A1  - Klimkiewicz, Anna
A1  - Łoczewska, Agata
A1  - Michalska, Aneta
A1  - Majewska, Aleksandra
A1  - Szejko, Natalia
A1  - Podgórska, Anna
A1  - Sołowiej, Małgorzata
A1  - Markuszewski, Leszek
A1  - Jakima, Sławomir
A1  - Płoski, Rafał
A1  - Brower, Kirk
A1  - Wojnar, Marcin
SP  - 125
EP  - 133
VL  - 14
IS  - 1
N2  - INTRODUCTION: Rape and pedophilic child molestation are the most commonly convicted sexual offenses in Poland. Recent studies have suggested a possible genetic contribution toward pathologic sexual interests and behaviors. <br><br>AIM: To analyze and compare functional polymorphisms of genes associated with the activity of the serotonin and dopamine systems in a group of paraphilic sexual offenders and control subjects. <br><br>METHODS: The study sample (n = 97) consisted of two groups: paraphilic sexual offenders (65 pedophilic child molesters and 32 rapists) and controls (n = 76). Genetic polymorphisms previously associated with behavioral control, addictive behaviors, and sexual functions were chosen for analyses. Specifically, functional polymorphisms in dopamine receptors genes (DRD1, DRD2, DRD4), catechol-O-methyltransferase gene (COMT), dopamine transporter gene (DAT), serotonin transporter gene (SLC6A4), serotonin type 2A receptor gene (5HTR2A), tryptophan hydroxylase 2 gene (TPH2), monoamine oxidase A gene (MAOA), and brain-derived neurotrophic factor gene (BDNF) were analyzed. MAIN OUTCOME MEASURES: An association between a history of sexual offense and the distribution of genotypes and alleles in the analyzed polymorphisms. <br><br>RESULTS: Our results found no association between a history of sexual offense and the distribution of genotypes or alleles in the analyzed polymorphisms. <br><br>CONCLUSION: Although these results are limited by the small sample and are exploratory, they highlight a novel approach to sample selection in a population that is difficult to access and study. Future research should include larger samples and other relevant polymorphisms to advance this field of study.<br><br>Copyright © 2016 International Society for Sexual Medicine. Published by Elsevier Inc. All rights reserved.<p />  <p>Language: en</p>
LA  - en
SN  - 1743-6095
UR  - http://dx.doi.org/10.1016/j.jsxm.2016.11.309
ID  - ref1
ER  -