TY  - JOUR
PY  - 2016//
TI  - Role of neurotoxicants and traumatic brain injury in α-synuclein protein misfolding and aggregation
JO  - Brain research bulletin
A1  - Rokad, Dharmin
A1  - Ghaisas, Shivani
A1  - Harischandra, Dilshan S.
A1  - Jin, Huajun
A1  - Anantharam, Vellareddy
A1  - Kanthasamy, Arthi
A1  - Kanthasamy, Anumantha G.
SP  - 60
EP  - 70
VL  - 133
IS  - 
N2  - Protein misfolding and aggregation are key pathological features of many neurodegenerative diseases including Parkinson's disease (PD) and other forms of human Parkinsonism. PD is a complex and multifaceted disorder whose etiology is not fully understood. However, several lines of evidence support the multiple hit hypothesis that genetic vulnerability and environmental toxicants converge to trigger PD pathology. Alpha-synuclein (α-Syn) aggregation in the brain is an important pathophysiological characteristic of synucleinopathies including PD. Epidemiological and experimental studies have shown that metals and pesticides play a crucial role in α-Syn aggregation leading to the onset of various neurodegenerative diseases including PD. In this review, we will emphasize key findings of several epidemiological as well as experimental studies of metal- and pesticide-induced α-Syn aggregation and neurodegeneration. We will also discuss other factors such as traumatic brain injury and oxidative insult in the context of α-Syn-related neurodegenerative processes.<br><br>Copyright © 2016. Published by Elsevier Inc.<p />  <p>Language: en</p>
LA  - en
SN  - 0361-9230
UR  - http://dx.doi.org/10.1016/j.brainresbull.2016.12.003
ID  - ref1
ER  -