TY  - JOUR
PY  - 2016//
TI  - Contrasting effects of posttraumatic stress disorder and mild traumatic brain injury on the whole-brain resting-state network: a magnetoencephalography study
JO  - Brain connectivity
A1  - Rowland, Jared
A1  - Stapleton-Kotloski, Jennifer
A1  - Alberto, Greg
A1  - Rawley, Justin
A1  - Kotloski, Robert
A1  - Taber, Katherine
A1  - Godwin, Dwayne
SP  - 45
EP  - 57
VL  - 7
IS  - 1
N2  - The aim of the current study was to evaluate alterations in whole-brain resting-state networks associated with posttraumatic stress disorder (PTSD) and mild traumatic brain injury (mTBI). Networks were constructed from locations of peak statistical power on an individual basis from magnetoencephalography (MEG) source series data by applying the weighted phase lag index and surrogate data thresholding procedures. Networks representing activity in the alpha bandwidth as well as wide band activity (DC-80 Hz) were created. Statistical comparisons were adjusted for age and education level. Alpha network results demonstrate reductions in network structure associated with PTSD, but no differences associated with mTBI. Wide band network results demonstrate a shift in connectivity from the alpha to theta bandwidth in both PTSD and mTBI. Also, contrasting alterations in network structure are noted, with increased randomness associated with PTSD and increased structure associated with mTBI. These results demonstrate the potential of the analysis of MEG resting-state networks to differentiate two highly comorbid conditions. The importance of the alpha bandwidth to resting state connectivity is also highlighted, while demonstrating the necessity of considering activity in other bandwidths during network construction.<p />  <p>Language: en</p>
LA  - en
SN  - 2158-0014
UR  - http://dx.doi.org/10.1089/brain.2015.0406
ID  - ref1
ER  -