TY  - JOUR
PY  - 2016//
TI  - BDNF Val66met polymorphism moderates the link between child maltreatment and reappraisal ability
JO  - Genes, brain and behavior
A1  - Miu, Andrei C.
A1  - Cărnuță, Mihai
A1  - Vulturar, Romana
A1  - Szekely-Copîndean, Raluca D.
A1  - Bîlc, Mirela I.
A1  - Chiș, Adina
A1  - Cioară, Marius
A1  - Fernandez, Katya C.
A1  - Szentágotai-Tătar, Aurora
A1  - Gross, James J.
SP  - 419
EP  - 426
VL  - 16
IS  - 4
N2  - Child maltreatment is associated with increased risk for virtually all common mental disorders, but it is not yet clear why. One possible mechanism is emotion regulation ability. The present study investigated for the first time the influence of a BDNF Val66Met genotype × child maltreatment interaction on emotion regulation, and compared differential susceptibility and diathesis-stress models. A sample of N = 254 healthy volunteers were genotyped for the BDNF Val66Met polymorphism and underwent an experimental assessment of reappraisal ability (i.e., the success of using reappraisal to downregulate negative affect). A self-report instrument previously validated against a clinical interview was used to investigate child maltreatment. There was a significant BDNF Val66Met genotype × child maltreatment interaction (B = -0.31, p < 0.015), with Met carriers showing both the lowest level of reappraisal ability in maltreated participants, and the highest level of reappraisal ability in non-maltreated participants. By assessing alternative models, we found that the best fitting model was in line with strong differential susceptibility. As expected, reappraisal ability was negatively correlated with depressive symptoms. Therefore, the BDNF Val66Met polymorphism moderates the link between child maltreatment and emotion regulation ability. Future studies could investigate whether improving reappraisal in maltreated BDNF Met carriers results in reduced risk for mental disorders.<br><br>This article is protected by copyright. All rights reserved.<p />  <p>Language: en</p>
LA  - en
SN  - 1601-1848
UR  - http://dx.doi.org/10.1111/gbb.12366
ID  - ref1
ER  -