TY  - JOUR
PY  - 2017//
TI  - False negative on a proven involuntary intoxication in two children with lorazepam
JO  - Annales de Biologie Clinique
A1  - Feliu, Catherine
A1  - Guillemin, Hélène
A1  - Gozalo, Claire
A1  - Fouley, Aurélie
A1  - Marty, Hélène
A1  - Millart, Hervé
A1  - Djerada, Zoubir
SP  - 83
EP  - 86
VL  - 75
IS  - 1
N2  - Children aged between 1 to 4 years are the most at risk of unintentional poisonings. Benzodiazepines are the most medicine often cause of the poisoning. Among the twenty-two most prescribed benzodiazepines in France, lorazepam ranks fifth behind zolpidem, alprazolam, bromazepam and zopiclone. However the automated assay currently available does not allow to detect and/or to quantify lorazepam. The alternative to the immunoassay is the liquid chromatography coupled with mass spectrometry (HPLC/MS). This technique, highly sensitive and specific, requires a pre-treatment phase and a good technical proficiency, justifying specialized staff. The clinical cases presented here illustrate the major interest of availability to this type of technology in routine and 24h/24h.<p />  <p>Language: en</p>
LA  - en
SN  - 0003-3898
UR  - http://dx.doi.org/10.1684/abc.2016.1209
ID  - ref1
ER  -