TY  - JOUR
PY  - 2016//
TI  - Pulmonary function test findings in patients with acute inhalation injury caused by smoke bombs
JO  - Journal of thoracic disease
A1  - Cao, Lu
A1  - Zhang, Xin-Gang
A1  - Wang, Jian-Guo
A1  - Wang, Han-Bin
A1  - Chen, Yi-Bing
A1  - Zhao, Da-Hui
A1  - Shi, Wen-Fang
A1  - Xie, Li-Xin
SP  - 3160
EP  - 3167
VL  - 8
IS  - 11
N2  - BACKGROUND: This study aimed to determine the effects of smoke bomb-induced acute inhalation injury on pulmonary function at different stages of lung injury. <br><br>METHODS: We performed pulmonary function tests (PFTs) in 15 patients with acute inhalation injury from days 3 to 180 after smoke inhalation. We measured the trace element zinc in whole blood on days 4 and 17, and correlations of zinc levels with PFTs were performed. <br><br>RESULTS: In the acute stage of lung injury (day 3), 3 of 11 patients with mild symptoms had normal pulmonary function and 8 patients with restrictive ventilatory dysfunction and reduced diffusing capacity. Some patients also had mild obstructive ventilatory dysfunction (5 patients) and a decline in small airway function (6 patients). For patients with severe symptoms, PFT results showed moderate to severe restrictive ventilatory dysfunction and reduced diffusing capacity. PaCO2 was significantly higher (P=0.047) in patients with reduced small airway function compared with those with normal small airway function. Whole blood zinc levels in the convalescence stage (day 17) were significantly lower than those in the acute stage (day 4). Zinc in the acute stage was negatively correlated with DLCO/VA on days 3, 10, and 46 (r=-0.633, -0.676, and -0.675 respectively, P<0.05). <br><br>CONCLUSIONS: Smoke inhalation injury mainly causes restrictive ventilatory dysfunction and reduced diffusing capacity, and causes mild obstructive ventilatory dysfunction and small airway function decline in some patients. Zinc is negatively correlated with DLCO/VA. Zinc levels may be able to predict prognosis and indicate the degree of lung injury.<p />  <p>Language: en</p>
LA  - en
SN  - 2072-1439
UR  - http://dx.doi.org/10.21037/jtd.2016.11.94
ID  - ref1
ER  -