TY  - JOUR
PY  - 2017//
TI  - Injury severity, sex, and transfusion volume, but not transfusion ratio, predict inflammatory complications after traumatic injury
JO  - Heart and lung
A1  - Jones, Allison R.
A1  - Bush, Heather M.
A1  - Frazier, Susan K.
SP  - 114
EP  - 119
VL  - 46
IS  - 2
N2  - BACKGROUND: Blood component (packed red blood cells [PRBC], fresh frozen plasma [FFP], platelets [PLT]) ratios transfused in a 1:1:1 fashion are associated with survival after trauma; the relationship among blood component ratios and inflammatory complications after trauma is not fully understood. <br><br>OBJECTIVES: To evaluate the relationship among blood component ratios (1:1 vs other for PRBC:FFP and PRBC:PLT) and inflammatory complications (primary outcome) in patients with major trauma. <br><br>METHODS: Secondary analysis of a multi-institution database (N = 1538). Survival methods were used to determine the relationship among blood component ratios and inflammatory complications. <br><br>RESULTS: Patients were primarily male (68%), Caucasians (89%), aged 39 ± 14 years, involved in a motor vehicle collision (53%). Eighty-six percent of patients developed an inflammatory complication; 76% developed organ failure, 27% ventilator-associated pneumonia, and 24% acute respiratory distress syndrome. Injury severity, sex, and total PRBC transfusion volume, not blood component ratio, predicted inflammatory complications. <br><br>CONCLUSIONS: Increased understanding of factors associated with inflammation after trauma and PRBC transfusion is needed.<br><br>Copyright © 2016 Elsevier Inc. All rights reserved.<p />  <p>Language: en</p>
LA  - en
SN  - 0147-9563
UR  - http://dx.doi.org/10.1016/j.hrtlng.2016.12.002
ID  - ref1
ER  -