TY  - JOUR
PY  - 2017//
TI  - Maoa and Maob polymorphisms and personality traits in suicide attempters and healthy controls: a preliminary study
JO  - Psychiatry research
A1  - Balestri, Martina
A1  - Calati, Raffaella
A1  - Serretti, Alessandro
A1  - Hartmann, Annette M.
A1  - Konte, Bettina
A1  - Friedl, Marion
A1  - Giegling, Ina
A1  - Rujescu, Dan
SP  - 212
EP  - 217
VL  - 249
IS  - 
N2  - Serotonergic neurotransmission dysfunctions have been well documented in patients with suicidal behaviour. We investigated monoamine oxidase A (MAOA: rs2064070, rs6323, rs909525) and B (MAOB: rs1799836, rs2311013, rs2205655) genetic modulation of personality traits (Temperament and Character Inventory, TCI) as endophenotype for suicidal behaviour. 108 suicide attempters and 286 healthy controls of German origin were screened. Among females, allelic analyses revealed associations between MAOA rs6323 A allele and higher Harm Avoidance in suicide attempters and MAOB rs2205655 A allele and higher Cooperativeness scores in healthy controls. Among males, MAOA rs909525 A allele was associated with higher Reward Dependence in suicide attempters. Multivariate analyses controlling for age and educational level mainly confirmed results. Case-control analyses in this subsample do not differ from our previously reported one. Despite of the small sample size, a possible involvement of these genes in the modulation of personality traits closely related to suicidal behaviour cannot be excluded.<br><br>Copyright © 2017 Elsevier Ireland Ltd. All rights reserved.<p />  <p>Language: en</p>
LA  - en
SN  - 0165-1781
UR  - http://dx.doi.org/10.1016/j.psychres.2017.01.020
ID  - ref1
ER  -