TY  - JOUR
PY  - 2017//
TI  - Head injury serum markers for assessing response to trauma: design of the HeadSMART study
JO  - Brain injury
A1  - Peters, Matthew E.
A1  - Rao, Vani
A1  - Bechtold, Kathleen T.
A1  - Roy, Durga
A1  - Sair, Haris I.
A1  - Leoutsakos, Jeannie-Marie
A1  - Diaz-Arrastia, Ramon
A1  - Stevens, Robert D.
A1  - Batty, D. Scott
A1  - Falk, Hayley
A1  - Fernandez, Christopher
A1  - Ofoche, Uju
A1  - Vassila, Alexandra
A1  - Hall, Anna J.
A1  - Anderson, Braden
A1  - Bessman, Edward
A1  - Lyketsos, Constantine G.
A1  - Everett, Allen D.
A1  - van Eyk, Jennifer
A1  - Korley, Frederick K.
SP  - 370
EP  - 378
VL  - 31
IS  - 3
N2  - BACKGROUND: Accurate diagnosis and risk stratification of traumatic brain injury (TBI) at time of presentation remains a clinical challenge. The Head Injury Serum Markers for Assessing Response to Trauma study (HeadSMART) aims to examine blood-based biomarkers for diagnosing and determining prognosis in TBI. <br><br>METHODS: HeadSMART is a 6-month prospective cohort study comparing emergency department patients evaluated for TBI (exposure group) to (1) emergency department patients evaluated for traumatic injury without head trauma and (2) healthy persons. Study methods and characteristics of the first 300 exposure participants are discussed. <br><br>RESULTS: Of the first 300 participants in the exposure arm, 70% met the American Congress of Rehabilitation Medicine criteria for TBI, with the majority (80.1%) classified as mild TBI. The majority of subjects in the exposure arm had Glasgow Coma Scale scores of 13-15 (98.0%), normal head computed tomography (81.3%) and no prior history of concussion (71.7%). <br><br>CONCLUSION: With systematic phenotyping, HeadSMART will facilitate diagnosis and risk-stratification of the heterogeneous group of individuals currently diagnosed with TBI.<p />  <p>Language: en</p>
LA  - en
SN  - 0269-9052
UR  - http://dx.doi.org/10.1080/02699052.2016.1231344
ID  - ref1
ER  -