TY  - JOUR
PY  - 2017//
TI  - Long-term mortality after poisoning with antipsychotics
JO  - Clinical toxicology (Philadelphia, Pa.)
A1  - Toft, Stine
A1  - Horwitz, Henrik
A1  - Dalhoff, Kim Peder
SP  - 267
EP  - 274
VL  - 55
IS  - 4
N2  - INTRODUCTION: The objective of this study was to investigate the long-term mortality and cause of death after deliberate self-poisoning with antipsychotics. Furthermore, we investigated the risk of repeated self-poisoning after a first episode of poisoning with antipsychotics. <br><br>METHODS: We identified patients with antipsychotic poisoning from the Danish Poison Information Centre Database and correlated their personal identification number with four Danish national registries related to health aspects. <br><br>RESULTS: From August 2006 to December 2013 we identified 2289 patients poisoned with antipsychotic agents. The average age of the patients was 35.6 years (SD 14.3) and 68.5% were women. Eleven patients died during the first 30 days, and at the end of follow-up in March 2014, 150 patients were deceased, leading to a mortality rate of 2.1 per 100 person-years and a standardized mortality ratio of 9.0. The most common causes of death were poisoning (29%) and violent suicide (18%) - however half of the patients died from natural reasons. 643 patients (28%) repeated the poisoning once or more. <br><br>CONCLUSIONS: Poisoning with antipsychotics was associated with an increased risk of death. Most of these deaths were preventable, and this highlights the need for secondary prophylaxis following a suicide attempt.<p />  <p>Language: en</p>
LA  - en
SN  - 1556-3650
UR  - http://dx.doi.org/10.1080/15563650.2017.1284328
ID  - ref1
ER  -