TY  - JOUR
PY  - 2017//
TI  - Increased ratio of high sensitivity C-reactive protein to interleukin-10 as a potential peripheral biomarker of schizophrenia and aggression
JO  - International journal of psychophysiology
A1  - Zhang, Qinting
A1  - Hong, Wu
A1  - Li, Haozhe
A1  - Peng, Fanglan
A1  - Wang, Fan
A1  - Li, Ningning
A1  - Xiang, Hui
A1  - Zhang, Zongfeng
A1  - Su, Yousong
A1  - Huang, Yueqi
A1  - Zhang, Shengyu
A1  - Zhao, Guoqin
A1  - Zhou, Rubai
A1  - Mao, Ling
A1  - Lin, Zhiguang
A1  - Cai, Weixiong
A1  - Fang, Yiru
A1  - Xie, Bin
A1  - Zhao, Min
SP  - 9
EP  - 15
VL  - 114
IS  - 
N2  - BACKGROUND: Many studies have indicated that immune dysfunction might be involved in the physiopathology of schizophrenia and aggression. This study aimed to investigate the correlation between high-sensitivity C-reactive protein (hsCRP), interleukin (IL)-10 and clinical characteristics,especially aggression, and to explore the potential role of hsCRP and IL-10 as plasma biomarkers of schizophrenia. <br><br>METHODS: Forty-one patients with schizophrenia and forty healthy individuals were enrolled. Psychopathological severity and aggression were assessed using the Positive and Negative Syndrome Scale (PANSS) and Modified Overt Aggression Scale (MOAS). Plasma concentrations of hsCRP and IL-10 were assessed by enzyme-linked immunosorbent assay (ELISA). <br><br>RESULTS: (1) Higher levels of hsCRP (p<0.001), lower levels of logIL-10 (p<0.001) and higher ratio of hsCRP to IL-10 (p<0.001) were observed in the plasma of patients with schizophrenia, compared to healthy controls; (2) ROC (receiver operating characteristic) curve analysis revealed that ratio of hsCRP/IL-10 (predictive value: 0.783, p<0.01; sensitivity: 85.4%; specificity: 67.5%) was more applicable as a biomarker to distinguish patients with schizophrenia from the control group than hsCRP and IL-10 alone (predictive value: 0.718, p<0.01; 0.275, p<0.001, respectively); (3) we found positive correlations between hsCRP and the total score and verbal aggression score of MOAS(r=0.654, p<0.01; r=0.678, p<0.05), and between hsCRP/IL-10 and the total score of MOAS (r=0.636, p<0.01). <br><br>CONCLUSIONS: Our results suggest the possible function of hsCRP and IL-10 in the pathogenesis of schizophrenia and the possible value of hsCRP/IL-10 as a potential peripheral biomarker of schizophrenia. This finding also suggests a relationship between hsCRP, IL-10 and their ratio with aggression in patients with schizophrenia.<br><br>Copyright © 2016. Published by Elsevier B.V.<p />  <p>Language: en</p>
LA  - en
SN  - 0167-8760
UR  - http://dx.doi.org/10.1016/j.ijpsycho.2017.02.001
ID  - ref1
ER  -