TY  - JOUR
PY  - 2017//
TI  - Toxicity of the venom of Latrodectus (Araneae: Theridiidae) spiders from different regions of Argentina and neutralization by therapeutic antivenoms
JO  - Toxicon: Journal of the International Society on Toxinology
A1  - de Roodt, Adolfo Rafael
A1  - Lanari, Laura Cecilia
A1  - Laskowicz, Rodrigo Daniel
A1  - Costa de Oliveira, Vanessa
A1  - Irazu, Lucia Elvira
A1  - González, Alda
A1  - Giambelluca, Luis
A1  - Nicolai, Néstor
A1  - Barragán, Javier Hugo
A1  - Ramallo, Leticia
A1  - López, Raúl Alfredo
A1  - Lopardo, Jorge
A1  - Jensen, Oscar
A1  - Larrieu, Edmundo
A1  - Calabró, Arnoldo
A1  - Vurcharchuc, Miriam Guadalupe
A1  - Lago, Néstor Rubén
A1  - García, Susana Isabel
A1  - de Titto, Ernesto Horacio
A1  - Damín, Carlos Fabián
SP  - 63
EP  - 72
VL  - 130
IS  - 
N2  - "Black widow" spiders belong to the genus Latrodectus and are one of the few spiders in the world whose bite can cause severe envenomation in humans and domestic animals. In Argentina, these spiders are distributed throughout the country and are responsible for the highest number of bites by spiders of toxicological sanitary interest. Here, we studied the toxicity and some biochemical and immunochemical characteristics of eighteen venom samples from Latrodectus spiders from eight different provinces of Argentina, and the neutralization of some of these samples by two therapeutic antivenoms used in the country for the treatment of envenomation and by a anti-Latrodectus antivenom prepared against the venom of Latrodectus mactans from Mexico. We observed important toxicity in all the samples studied and a variation in the toxicity of samples, even in those from the same region and province and even in the same Latrodectus species from the same region. The therapeutic antivenoms efficiently neutralized all the venoms studied.<br><br>Copyright © 2017 Elsevier Ltd. All rights reserved.<p />  <p>Language: en</p>
LA  - en
SN  - 0041-0101
UR  - http://dx.doi.org/10.1016/j.toxicon.2017.02.029
ID  - ref1
ER  -