TY  - JOUR
PY  - 2017//
TI  - Trends in antipsychotic prescriptions for Japanese outpatients during 2006-2012: a descriptive epidemiological study
JO  - Pharmacoepidemiology and drug safety
A1  - Kochi, Kenji
A1  - Sato, Izumi
A1  - Nishiyama, Chika
A1  - Tanaka-Mizuno, Sachiko
A1  - Doi, Yuko
A1  - Arai, Masaru
A1  - Fujii, Yosuke
A1  - Matsunaga, Toshiyuki
A1  - Ogawa, Yusuke
A1  - Furukawa, Toshi A.
A1  - Kawakami, Koji
SP  - 642
EP  - 656
VL  - 26
IS  - 6
N2  - PURPOSE: This study aimed to assess the trends in antipsychotic prescriptions for outpatients in Japan, where a community-based approach to mental healthcare is emphasized. <br><br>METHODS: This descriptive epidemiological study used claims data from 1038 community pharmacies across Japan. Outpatients who were ≥18 years old and receiving their initial antipsychotic prescription during 2006-2012 were evaluated. The annual trends were reported for monotherapies, polypharmacy, antipsychotic doses, and the concurrent prescription of psychotropic medications. <br><br>RESULTS: The 152 592 outpatients included 101 133 (66%) adults (18-64 years old) and 51 459 (34%) older adults (≥65 years old). Among the adults, second-generation antipsychotic monotherapy prescriptions increased from 49% in 2006 to 71% in 2012, first-generation antipsychotic monotherapy prescriptions decreased from 29 to 14%, and antipsychotic polypharmacy decreased from 23 to 15%, respectively. Among the older adults, second-generation antipsychotic monotherapy prescriptions increased from 64 to 82%, first-generation antipsychotic monotherapy prescriptions decreased from 29 to 12%, and antipsychotic polypharmacy decreased from 7 to 6%, respectively. During the study period, >80% of the adults and >90% of the older adults received antipsychotics at risperidone-equivalent doses of <6 mg/day. Anxiolytics/hypnotics, antidepressants, antiparkinson agents, mood stabilizers, and anti-dementia agents were concurrently prescribed with antipsychotics for 70, 33, 20, 20, and 0.3% of the adults and for 43, 16, 19, 8, and 16% of the older adults, respectively. <br><br>CONCLUSIONS: The present study evaluated large-scale claims-based datasets and found that high-dose prescriptions and antipsychotic polypharmacy among Japanese outpatients were not as prevalent as has been previously thought. Copyright © 2017 John Wiley & Sons, Ltd. StartCopTextCopyright © 2017 John Wiley & Sons, Ltd.<br><br>Copyright © 2017 John Wiley & Sons, Ltd.<p />  <p>Language: en</p>
LA  - en
SN  - 1053-8569
UR  - http://dx.doi.org/10.1002/pds.4187
ID  - ref1
ER  -