TY  - JOUR
PY  - 2017//
TI  - Diverging white matter trajectories in children after traumatic brain injury: the RAPBI study
JO  - Neurology
A1  - Dennis, Emily L.
A1  - Rashid, Faisal
A1  - Ellis, Monica U.
A1  - Babikian, Talin
A1  - Vlasova, Roza M.
A1  - Villalon-Reina, Julio E.
A1  - Jin, Yan
A1  - Olsen, Alexander
A1  - Mink, Richard
A1  - Babbitt, Christopher J.
A1  - Johnson, Jeffrey
A1  - Giza, Christopher C.
A1  - Thompson, Paul M.
A1  - Asarnow, Robert F.
SP  - 1392
EP  - 1399
VL  - 88
IS  - 15
N2  - OBJECTIVE: To examine longitudinal trajectories of white matter organization in pediatric moderate/severe traumatic brain injury (msTBI) over a 12-month period. <br><br>METHODS: We studied 21 children (16 M/5 F) with msTBI, assessed 2-5 months postinjury and again 13-19 months postinjury, as well as 20 well-matched healthy control children. We assessed corpus callosum function through interhemispheric transfer time (IHTT), measured using event-related potentials, and related this to diffusion-weighted MRI measures of white matter (WM) microstructure. At the first time point, half of the patients with TBI had significantly slower IHTT (TBI-slow-IHTT, n = 11) and half were in the normal range (TBI-normal-IHTT, n = 10). <br><br>RESULTS: The TBI-normal-IHTT group did not differ significantly from healthy controls, either in WM organization in the chronic phase or in the longitudinal trajectory of WM organization between the 2 evaluations. In contrast, the WM organization of the TBI-slow-IHTT group was significantly lower than in healthy controls across a large portion of the WM. Longitudinal analyses showed that the TBI-slow-IHTT group experienced a progressive decline between the 2 evaluations in WM organization throughout the brain. <br><br>CONCLUSIONS: We present preliminary evidence suggesting a potential biomarker that identifies a subset of patients with impaired callosal organization in the first months postinjury who subsequently experience widespread continuing and progressive degeneration in the first year postinjury.<br><br>© 2017 American Academy of Neurology.<p />  <p>Language: en</p>
LA  - en
SN  - 0028-3878
UR  - http://dx.doi.org/10.1212/WNL.0000000000003808
ID  - ref1
ER  -