TY  - JOUR
PY  - 2017//
TI  - Baclofen and alcohol-dependent patients: a real risk of severe self-poisoning
JO  - Basic and Clinical Pharmacology and Toxicology
A1  - Boels, David
A1  - Victorri-Vigneau, Caroline
A1  - Grall-Bronnec, Marie
A1  - Touré, Ali
A1  - Garnier, Anais
A1  - Turcant, Alain
A1  - Le Roux, Gaël
SP  - 353
EP  - 359
VL  - 121
IS  - 4
N2  - Baclofen is often prescribed in high doses to fight cravings experienced by alcohol-dependent patients. Such an increase in the availability of baclofen is concerning. This study aimed to determine the change in number and profile of self-poisoning with baclofen over time, since baclofen has become increasingly popular, in order to describe the severity of self-poisoning with baclofen and to focus on co-existing alcohol use disorders and psychiatric illnesses determine predictors of severity. This was a retrospective study of self-poisoning with baclofen as reported by the western France Poison Control Center (PCC), which represents a population of more than 12 million people from January 2008 to March 2014. 111 cases of self-poisoning with baclofen were reported to the western France PCC (62 males and 49 females; average age 39±12). Poisoning severities were: "null" (9 cases), "minor" (37 cases), "moderate" (19 cases) and "high" (46 cases, including 4 deaths). The most frequently reported symptoms were neurological (45%) and cardiovascular (27%). The severity was significantly associated with psychiatric disorders (OR=2.9; p=0.03). Baclofen, prescribed in high doses, may lead to severe poisoning, particularly in patients with psychiatric illnesses. Authorities should put forward a new policy for prescribing the drug as a treatment for alcohol dependence. This article is protected by copyright. All rights reserved.<br><br>This article is protected by copyright. All rights reserved.<p />  <p>Language: en</p>
LA  - en
SN  - 1742-7835
UR  - http://dx.doi.org/10.1111/bcpt.12779
ID  - ref1
ER  -