TY  - JOUR
PY  - 2017//
TI  - Factors affecting increased risk for substance use disorders following traumatic brain injury: what we can learn from animal models
JO  - Neuroscience and biobehavioral reviews
A1  - Merkel, Steven F.
A1  - Cannella, Lee Anne
A1  - Razmpour, Roshanak
A1  - Lutton, Evan
A1  - Raghupathi, Ramesh
A1  - Rawls, Scott M.
A1  - Ramirez, Servio H.
SP  - 209
EP  - 218
VL  - 77
IS  - 
N2  - Recent studies have helped identify multiple factors affecting increased risk for substance use disorders (SUDs) following traumatic brain injury (TBI). These factors include age at the time of injury, repetitive injury and TBI severity, neurocircuits, neurotransmitter systems, neuroinflammation, and sex differences. This review will address each of these factors by discussing 1) the clinical and preclinical data identifying patient populations at greatest risk for SUDs post-TBI, 2) TBI-related neuropathology in discrete brain regions heavily implicated in SUDs, and 3) the effects of TBI on molecular mechanisms that may drive substance abuse behavior, like dopaminergic and glutamatergic transmission or neuroimmune signaling in mesolimbic regions of the brain. Although these studies have laid the groundwork for identifying factors that affect risk of SUDs post-TBI, additional studies are required. Notably, preclinical models have been shown to recapitulate many of the behavioral, cellular, and neurochemical features of SUDs and TBI. Therefore, these models are well suited for answering important questions that remain in future investigations.<br><br>Copyright © 2017. Published by Elsevier Ltd.<p />  <p>Language: en</p>
LA  - en
SN  - 0149-7634
UR  - http://dx.doi.org/10.1016/j.neubiorev.2017.03.015
ID  - ref1
ER  -