TY - JOUR PY - 2017// TI - Modeling neurocognitive decline and recovery during repeated cycles of extended sleep and chronic sleep deficiency JO - Sleep A1 - St Hilaire, Melissa A. A1 - Rüger, Melanie A1 - Fratelli, Federico A1 - Hull, Joseph T. A1 - Phillips, Andrew J. K. A1 - Lockley, Steven W. SP - e09 EP - e09 VL - 40 IS - 1 N2 - STUDY OBJECTIVES: Intraindividual night-to-night sleep duration is often insufficient and variable. Here we report the effects of such chronic variable sleep deficiency on neurobehavioral performance and the ability of state-of-the-art models to predict these changes.

METHODS: Eight healthy males (mean age METHODS: ± SD: 23.9 ± 2.4 years) studied at our inpatient intensive physiologic monitoring unit completed an 11-day protocol with a baseline 10-hour sleep opportunity and three cycles of two 3-hour time-in-bed (TIB) and one 10-hour TIB sleep opportunities. Participants received one of three polychromatic w METHODS: hite light interventions (200 lux 4100K, 200 or 400 lux 17000K) for 3.5 hours on the morning following the second 3-hour TIB opportunity each cycle. Neurocognitive performance was assessed using the psychomotor vigilance test (PVT) administered every 1-2 hours. PVT data were compared to predictions METHODS: of five group-average mathematical models that incorporate chronic sleep loss functions.

RESULTS: While PVT performance deteriorated cumulatively following each cycle of two 3-hour sleep opportunities, and improved following each 10-hour sleep opportunity, performance declined cumulatively throughout the protocol at a more accelerated rate than predicted by state-of-the-art group-average mathematical models. Subjective sleepiness did not reflect performance. The light interventions had minimal effect.

CONCLUSIONS: Despite apparent recovery following each extended sleep opportunity, residual performance impairment remained and deteriorated rapidly when rechallenged with subsequent sleep loss. None of the group-average models were capable of predicting both the build-up in impairment and recovery profile of performance observed at the group or individual level, raising concerns regarding their use in real-world settings to predict performance and improve safety.

Language: en

LA - en SN - 0161-8105 UR - http://dx.doi.org/10.1093/sleep/zsw009 ID - ref1 ER -