TY  - JOUR
PY  - 2017//
TI  - Neural reactivity to reward and internalizing symptom dimensions
JO  - Journal of affective disorders
A1  - Burkhouse, Katie L.
A1  - Gorka, Stephanie M.
A1  - Afshar, Kaveh
A1  - Phan, K. Luan
SP  - 73
EP  - 79
VL  - 217
IS  - 
N2  - BACKGROUND: Reduced reward responsiveness, measured via the event-related potential (ERP) component the reward positivity (RewP), has been linked to several internalizing psychopathologies (IPs). Specifically, prior studies suggest that a reduced RewP is robustly related to depression and to a lesser extent anxiety. No studies to date, however, have examined the relation between the RewP and IP symptom dimensions in a heterogeneous, clinically representative patient population that includes both depressed and/or anxious subjects. The primary aim of the current study was to examine the relation between the RewP and specific internalizing symptom dimensions among patients with a variety of IP diagnoses and symptoms. <br><br>METHODS: A total of 80 treatment seeking adults from the community completed a battery of questionnaires assessing a range of IP symptoms and a well-validated reward processing task known to robustly elicit the RewP. <br><br>RESULTS: A principal components analysis (PCA) on clinical assessments revealed two distinct factors that characterized the patient sample: affective distress/misery and fear-based anxiety. <br><br>RESULTS showed that within this sample, an attenuated RewP was associated with greater affective distress/misery based symptoms; however, the RewP was unrelated to fear-based anxiety symptoms. <br><br>CONCLUSIONS: The current findings suggest that patients with higher distress/misery symptoms are characterized by decreased responsivity to rewards at the physiological level, and that this response tendency distinguishes distress/misery symptoms from fear-based symptoms. The RewP may be one promising transdiagnostic biological target for intervention efforts for individuals with distress-based symptoms of psychopathology.<br><br>Copyright © 2017 Elsevier B.V. All rights reserved.<p />  <p>Language: en</p>
LA  - en
SN  - 0165-0327
UR  - http://dx.doi.org/10.1016/j.jad.2017.03.061
ID  - ref1
ER  -