TY  - JOUR
PY  - 2015//
TI  - Impact of depression on progression of impairment and disability in early Parkinson's disease
JO  - Movement disorders clinical practice
A1  - Bega, Danny
A1  - Luo, Sheng
A1  - Fernandez, Hubert
A1  - Chou, Kelvin
A1  - Aminoff, Michael
A1  - Parashos, Sotirios
A1  - Walker, Harrison
A1  - Russell, David S.
A1  - Christine, Chadwick W.
A1  - Dhall, Rohit
A1  - Singer, Carlos
A1  - Bodis-Wollner, Ivan
A1  - Hamill, Robert
A1  - Truong, Daniel
A1  - Mari, Zoltan
A1  - Glazmann, Sofya
A1  - Huang, Meilin
A1  - Houston, Emily
A1  - Simuni, Tanya
SP  - 371
EP  - 378
VL  - 2
IS  - 4
N2  - BACKGROUND: Depression is one of the most common nonmotor symptoms associated with Parkinson's disease (PD), yet the impact of depression on progression of disease is unclear. <br><br>OBJECTIVE: The aim of this study was to prospectively characterize the relationship between depressive symptoms and measures of disease progression in a large sample of patients with early, medically treated PD. <br><br>METHODS: Baseline and longitudinal Beck Depression Inventory (BDI) scores from participants in the NINDS Exploratory Trials in PD Long Term Study 1 were correlated with changes in multiple measures of disease severity over 5 years. Multivariate analysis of predictors of change in BDI was performed. <br><br>RESULTS: Of 1,741 participants, 746 completed 5-year assessments and were included. Mean age was 62.00 years (standard deviation [SD]: 9.22) and mean disease duration was 1.69 years (SD, 1.16). Mean BDI score was 6.24 (SD, 5.02) at baseline and 8.57 (SD, 6.60) at 5 years. Baseline BDI score was strongly associated with rate of change in all examined measures of disease severity. In multivariate analysis, BDI 5-year change was associated with change in UPDRS Part I (excluding depression item; P < 0.01), 33-item Parkinson's Disease Questionnaire (P < 0.01), EuroQOL Five Dimensional Questionnaire (P = 0.02), and Total Functional Capacity (P < 0.01), but was not associated with motor or cognitive measures. This model explained 68.8% of the variance 5-year change of the BDI score. <br><br>CONCLUSIONS: Worse baseline BDI scores are associated with a decline in multiple measures of disease severity in PD. Worsening of BDI at 5 years was associated with worsening in UPDRS Part I and quality-of-life measures, but not with motor or cognitive measures.<p />  <p>Language: en</p>
LA  - en
SN  - 2330-1619
UR  - http://dx.doi.org/10.1002/mdc3.12205
ID  - ref1
ER  -